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dc.contributor.authorPandeya, N.
dc.contributor.authorMcLeod, D.
dc.contributor.authorBalasubramaniam, K.
dc.contributor.authorBaade, Peter
dc.contributor.authorYoul, Philippa
dc.contributor.authorBain, Christopher J.
dc.contributor.authorAllison, R.
dc.contributor.authorJordan, Susan J.
dc.date.accessioned2017-05-19T03:57:15Z
dc.date.available2017-05-19T03:57:15Z
dc.date.issued2016
dc.identifier.issn0300-0664en_US
dc.identifier.doi10.1111/cen.12724en_US
dc.identifier.urihttp://hdl.handle.net/10072/69462
dc.description.abstractBackground: Thyroid cancer incidence has been increasing worldwide. Some suggest greater ascertainment of indolent tumours is the only driver, but others suggest there has been a true increase. Increases in Australia appear to have been among the largest in the world, so we investigated incidence trends in the Australian state of Queensland to help understand reasons for the rise. Methods: Thyroid cancers diagnoses in Queensland 1982–2008 were ascertained from the Queensland Cancer Registry. We calculated age-standardized incidence rates (ASR) and used Poisson regression to estimate annual percentage change (APC) in thyroid cancer incidence by socio-demographic and tumour-related factors. Results: Thyroid cancer ASR in Queensland increased from 2·2 to 10·6/100 000 between 1982 and 2008 equating to an APC of 5·5% [95% confidence interval (CI) 4·7–6·4] in men and 6·1% (95% CI 5·5–6·6) in women. The rise was evident, and did not significantly differ, across socio-economic and remoteness-of-residence categories. The largest increase seen was in the papillary subtype in women (APC 7·9%, 95% CI 7·3–8·5). Incidence of localized and more advanced-stage cancers rose over time although the increase was greater for early-stage cancers. Conclusion: There has been a marked increase in thyroid cancer incidence in Queensland. The increase is evident in men and women across all adult age groups, socio-economic strata and remoteness-of-residence categories as well as in localized and more advanced-stage cancers. Our results suggest ‘overdiagnosis’ may not entirely explain rising incidence. Contemporary aetiological data and individual-level information about diagnostic circumstances are required to further understand reasons for rising thyroid cancer incidence.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherWiley-Blackwell Publishingen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom257en_US
dc.relation.ispartofpageto264en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalClinical Endocrinologyen_US
dc.relation.ispartofvolume84en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchOncology and Carcinogenesis not elsewhere classifieden_US
dc.subject.fieldofresearchcode111299en_US
dc.titleIncreasing thyroid cancer incidence in Queensland, Australia 1982-2008 - true increase or over-diagnosis?en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
dc.description.versionPost-printen_US
gro.rights.copyright© 2015 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Increasing thyroid cancer incidence in Queensland, Australia 1982-2008 - true increase or over-diagnosis?, Clinical Endocrinology, Volume 84, Issue 2, February 2016, Pages 257–264 which has been published in final form at http://dx.doi.org/10.1111/cen.12724. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.htmlen_US
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