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dc.contributor.authorPandeya, N
dc.contributor.authorMcLeod, DS
dc.contributor.authorBalasubramaniam, K
dc.contributor.authorBaade, PD
dc.contributor.authorYoul, PH
dc.contributor.authorBain, CJ
dc.contributor.authorAllison, R
dc.contributor.authorJordan, SJ
dc.date.accessioned2017-05-19T03:57:15Z
dc.date.available2017-05-19T03:57:15Z
dc.date.issued2016
dc.identifier.issn0300-0664
dc.identifier.doi10.1111/cen.12724
dc.identifier.urihttp://hdl.handle.net/10072/69462
dc.description.abstractBackground: Thyroid cancer incidence has been increasing worldwide. Some suggest greater ascertainment of indolent tumours is the only driver, but others suggest there has been a true increase. Increases in Australia appear to have been among the largest in the world, so we investigated incidence trends in the Australian state of Queensland to help understand reasons for the rise. Methods: Thyroid cancers diagnoses in Queensland 1982–2008 were ascertained from the Queensland Cancer Registry. We calculated age-standardized incidence rates (ASR) and used Poisson regression to estimate annual percentage change (APC) in thyroid cancer incidence by socio-demographic and tumour-related factors. Results: Thyroid cancer ASR in Queensland increased from 2·2 to 10·6/100 000 between 1982 and 2008 equating to an APC of 5·5% [95% confidence interval (CI) 4·7–6·4] in men and 6·1% (95% CI 5·5–6·6) in women. The rise was evident, and did not significantly differ, across socio-economic and remoteness-of-residence categories. The largest increase seen was in the papillary subtype in women (APC 7·9%, 95% CI 7·3–8·5). Incidence of localized and more advanced-stage cancers rose over time although the increase was greater for early-stage cancers. Conclusion: There has been a marked increase in thyroid cancer incidence in Queensland. The increase is evident in men and women across all adult age groups, socio-economic strata and remoteness-of-residence categories as well as in localized and more advanced-stage cancers. Our results suggest ‘overdiagnosis’ may not entirely explain rising incidence. Contemporary aetiological data and individual-level information about diagnostic circumstances are required to further understand reasons for rising thyroid cancer incidence.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.publisherWiley-Blackwell Publishing
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom257
dc.relation.ispartofpageto264
dc.relation.ispartofissue2
dc.relation.ispartofjournalClinical Endocrinology
dc.relation.ispartofvolume84
dc.rights.retentionY
dc.subject.fieldofresearchOncology and Carcinogenesis not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.subject.fieldofresearchcode111299
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1114
dc.titleIncreasing thyroid cancer incidence in Queensland, Australia 1982-2008 - true increase or over-diagnosis?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionPost-print
gro.rights.copyright© 2015 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Increasing thyroid cancer incidence in Queensland, Australia 1982-2008 - true increase or over-diagnosis?, Clinical Endocrinology, Volume 84, Issue 2, February 2016, Pages 257–264 which has been published in final form at http://dx.doi.org/10.1111/cen.12724. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html
gro.hasfulltextFull Text
gro.griffith.authorYoul, Philippa
gro.griffith.authorBaade, Peter D.


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