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dc.contributor.authorThekke Palasseri, Vipinen_US
dc.contributor.authorSakellaris, Harryen_US
dc.contributor.editorGadd & Sariaslanien_US
dc.date.accessioned2015-07-16en_US
dc.date.accessioned2015-09-04T02:34:56Z
dc.date.accessioned2017-03-02T00:14:59Z
dc.date.available2015-09-04T02:34:56Z
dc.date.available2017-03-02T00:14:59Z
dc.date.issued2015en_US
dc.identifier.issn0065-2164en_US
dc.identifier.doi10.1016/bs.aambs.2014.09.003en_US
dc.identifier.urihttp://hdl.handle.net/10072/69502
dc.description.abstractEnterotoxigenic Escherichia coli (ETEC) is a major cause of life-threatening diarrheal disease around the world. The major aspects of ETEC virulence are colonization of the small intestine and the secretion of enterotoxins which elicit diarrhea. Intestinal colonization is mediated, in part, by adhesins displayed on the bacterial cell surface. As colonization of the intestine is the critical first step in the establishment of an infection, it represents a potential point of intervention for the prevention of infections. Therefore, colonization factors (CFs) have been important subjects of research in the field of ETEC virulence. Research in this field has revealed that ETEC possesses a large array of serologically distinct CFs that differ in composition, structure, and function. Most ETEC CFs are pili (fimbriae) or related fibrous structures, while other adhesins are simple outer membrane proteins lacking any macromolecular structure. This chapter reviews the genetics, structure, function, and regulation of ETEC CFs and how such studies have contributed to our understanding of ETEC virulence and opened up potential opportunities for the development of preventive and therapeutic interventions.en_US
dc.description.peerreviewedNoen_US
dc.description.publicationstatusYesen_US
dc.publisherAcademic Pressen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofbookorjournalAdvances in Applied Microbiologyen_US
dc.relation.ispartofstudentpublicationYen_US
dc.relation.ispartofpagefrom155en_US
dc.relation.ispartofpageto197en_US
dc.relation.ispartofvolume90en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchPRE2009-Medical Bacteriologyen_US
dc.subject.fieldofresearchcode320401en_US
dc.titleColonization Factors of Enterotoxigenic Escherichia colien_US
dc.typeReport
dc.type.descriptionMajor Reviews/Reportsen_US
dc.type.codeden_US
gro.facultyGriffith Health Facultyen_US
gro.hasfulltextNo Full Text
gro.griffith.authorThekke Palasseri, Vipin Madhavan M.
gro.griffith.authorSakellaris, Harry


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