Show simple item record

dc.contributor.authorZhu, Xing-Quan
dc.contributor.authorKorhonen, Pasi K
dc.contributor.authorCai, Huimin
dc.contributor.authorYoung, Neil D
dc.contributor.authorNejsum, Peter
dc.contributor.authorvon Samson-Himmelstjerna, Georg
dc.contributor.authorBoag, Peter R
dc.contributor.authorTan, Patrick
dc.contributor.authorLi, Qiye
dc.contributor.authorMin, Jiumeng
dc.contributor.authorYang, Yulan
dc.contributor.authorWang, Xiuhua
dc.contributor.authorFang, Xiaodong
dc.contributor.authorHall, Ross S
dc.contributor.authorHofmann, Andreas
dc.contributor.authorSternberg, Paul W
dc.contributor.authorJex, Aaron R
dc.contributor.authorGasser, Robin B
dc.date.accessioned2017-05-03T15:19:26Z
dc.date.available2017-05-03T15:19:26Z
dc.date.issued2015
dc.identifier.issn2041-1723
dc.identifier.doi10.1038/ncomms7145
dc.identifier.urihttp://hdl.handle.net/10072/69561
dc.description.abstractToxocara canis is a zoonotic parasite of major socioeconomic importance worldwide. In humans, this nematode causes disease (toxocariasis) mainly in the under-privileged communities in developed and developing countries. Although relatively well studied from clinical and epidemiological perspectives, to date, there has been no global investigation of the molecular biology of this parasite. Here we use next-generation sequencing to produce a draft genome and transcriptome of T. canis to support future biological and biotechnological investigations. This genome is 317?Mb in size, has a repeat content of 13.5% and encodes at least 18,596 protein-coding genes. We study transcription in a larval, as well as adult female and male stages, characterize the parasite's gene-silencing machinery, explore molecules involved in development or host-parasite interactions and predict intervention targets. The draft genome of T. canis should provide a useful resource for future molecular studies of this and other, related parasites.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent487178 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom6145-1
dc.relation.ispartofpageto6145-8
dc.relation.ispartofjournalNature Communications
dc.relation.ispartofvolume6
dc.rights.retentionY
dc.subject.fieldofresearchMedical parasitology
dc.subject.fieldofresearchcode320704
dc.titleGenetic blueprint of the zoonotic pathogen Toxocara canis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-sa/4.0/
gro.rights.copyright© The Author(s) 2014. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
gro.hasfulltextFull Text
gro.griffith.authorHofmann, Andreas


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record