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dc.contributor.authorMuhammad, Faheem
dc.contributor.authorWang, Aifei
dc.contributor.authorMiao, Lu
dc.contributor.authorWang, Pengyuan
dc.contributor.authorLi, Qin
dc.contributor.authorLiu, Jia
dc.contributor.authorDu, Jianshi
dc.contributor.authorZhu, Guangshan
dc.date.accessioned2017-05-03T16:05:13Z
dc.date.available2017-05-03T16:05:13Z
dc.date.issued2015
dc.identifier.issn0743-7463
dc.identifier.doi10.1021/la503922j
dc.identifier.urihttp://hdl.handle.net/10072/69583
dc.description.abstractOur immune system uses toxicity of hydrogen peroxide to kill off bacterial invaders. In this contribution, we intended to integrate ROS producing capability of immune system with oxidant-sensitive nature of antibacterial silver nanoparticles (Ag NPs) to develop an oxidant drug delivery system. Prior to execute this strategy, we have developed an efficient one-pot synthetic protocol to produce ultrasmall (5 nm), water-stable, and oxidant-prone Ag NPs. Notably, the yield of as-synthesized Ag NPs is 10-fold higher than standard citrate reduction route. The resulting therapeutically active and well-dispersed Ag NPs are used as nanolids to cap the drug loaded nanochannels of porous silica. Upon exposing to H2O2, dissolution-accompanied aggregation of Ag nanolids unleashes the encapsulated therapeutic entities from channels of nanocarrier. Combination of antibacterial and anti-inflammatory drugs in single nanocarriers can potentially augment the effectiveness of various therapies.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom514
dc.relation.ispartofpageto521
dc.relation.ispartofjournalLangmuir
dc.relation.ispartofvolume31
dc.rights.retentionY
dc.subject.fieldofresearchEnvironmental engineering not elsewhere classified
dc.subject.fieldofresearchcode401199
dc.titleSynthesis of Oxidant Prone Nanosilver To Develop H2O2 Responsive Drug Delivery System
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorLi, Qin


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