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  • Sero-prevalence of antibodies to hepatitis A virus among Australian blood donors.

    Author(s)
    Young, Megan Kay
    Cripps, Allan W.
    Nimmo, Graeme
    Ji, Yu
    Fryk, Jesse
    Faddy, Helen
    Flower, Robert
    Griffith University Author(s)
    Young, Megan K.
    Cripps, Allan W.
    Year published
    2014
    Metadata
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    Abstract
    Aim: Australia has a low incidence of hepatitis A virus (HAV), with the majority of cases in travellers. Nonetheless, the sero-prevalence of antibodies against HAV among Victorians has increased over the last two decades, likely to be a result of vaccination and increased travel/immigration. This study measured the prevelance of HAV antibodies in blood donors from around Australia to determine if a similar rate exists in other states. Methods: Samples were collected from donors between January and July 2011 from Australian capital cities. All samples (n = 2109) were tested with a commercially available enzyme immunoassay ...
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    Aim: Australia has a low incidence of hepatitis A virus (HAV), with the majority of cases in travellers. Nonetheless, the sero-prevalence of antibodies against HAV among Victorians has increased over the last two decades, likely to be a result of vaccination and increased travel/immigration. This study measured the prevelance of HAV antibodies in blood donors from around Australia to determine if a similar rate exists in other states. Methods: Samples were collected from donors between January and July 2011 from Australian capital cities. All samples (n = 2109) were tested with a commercially available enzyme immunoassay for total anti-HAV antibody (levels >=20 IU/mL were considered sero-positive). Results: Anti-HAV antibody was detected in 51.4% (95% CI 49.27-53.53%) of donors. Some variability was observed between cities; the highest rates were seen in Sydney donors (57.33%; 95% CI 51.74-62.93%), while the lowest in donors from Brisbane (43.67%; 95% CI 38.05-49.28%). Not surprisingly, sero-prevelance increased with increasing donor age. Conclusions: This study demonstrated that over half of donors tested had anti-HAV antibodies, with relatively high rates in all capital cities. Given increased HAV vaccination rates, measuring naturally-acquired HAV infection in blood donors has become increasingly difficult and a serological test discriminating naturally-occurring from vaccine-induced immunity may be of interest.
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    Journal Title
    Pathology
    Volume
    46
    Issue
    suppl
    DOI
    https://doi.org/10.1097/01.PAT.0000443637.91688.1b
    Subject
    Medical and Health Sciences not elsewhere classified
    Clinical Sciences
    Publication URI
    http://hdl.handle.net/10072/69643
    Collection
    • Journal articles

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