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dc.contributor.authorGorayski, Peter
dc.contributor.authorFitzgerald, Rhys
dc.contributor.authorBarry, Tamara
dc.contributor.authorBurmeister, Elizabeth
dc.contributor.authorFoote, Matthew
dc.date.accessioned2017-05-03T12:44:43Z
dc.date.available2017-05-03T12:44:43Z
dc.date.issued2014
dc.identifier.issn20513909
dc.identifier.doi10.1002/jmrs.45
dc.identifier.urihttp://hdl.handle.net/10072/70075
dc.description.abstractIntroduction Cutaneous squamous cell carcinoma with large nerve perineural (LNPN) infiltration of the base of skull is a radiotherapeutic challenge given the complex target volumes to nearby organs at risk (OAR). A comparative planning study was undertaken to evaluate dosimetric differences between volumetric modulated arc therapy (VMAT) versus intensity modulated radiation therapy (IMRT) in the treatment of LNPN. Methods Five consecutive patients previously treated with IMRT for LNPN were selected. VMAT plans were generated for each case using the same planning target volumes (PTV), dose prescriptions and OAR constraints as IMRT. Comparative parameters used to assess target volume coverage, conformity and homogeneity included V95 of the PTV (volume encompassed by the 95% isodose), conformity index (CI) and homogeneity index (HI). In addition, OAR maximum point doses, V20, V30, non-target tissue (NTT) point max doses, NTT volume above reference dose, monitor units (MU) were compared. Results IMRT and VMAT plans generated were comparable for CI (P = 0.12) and HI (P = 0.89). VMAT plans achieved better V95 (P = < 0.001) and reduced V20 and V30 by 652 cubic centimetres (cc) (28.5%) and 425.7 cc (29.1%), respectively. VMAT increased MU delivered by 18% without a corresponding increase in NTT dose. Conclusion Compared with IMRT plans for LNPN, VMAT achieved comparable HI and CI.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent748195 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom85
dc.relation.ispartofpageto90
dc.relation.ispartofissue2
dc.relation.ispartofjournalJournal of Medical Radiation Sciences
dc.relation.ispartofvolume61
dc.rights.retentionY
dc.subject.fieldofresearchNursing not elsewhere classified
dc.subject.fieldofresearchcode111099
dc.titleVolumetric modulated arc therapy versus step-and-shoot intensity modulated radiation therapy in the treatment of large nerve perineural spread to the skull base: A comparative dosimetric planning study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2014 The Authors. Journal of Medical Radiation Sciences published by Wiley Publishing Asia Pty Ltd on behalf of Australian Institute of Radiography and New Zealand Institute of Medical Radiation Technology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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gro.griffith.authorBurmeister, Elizabeth


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