dc.contributor.author | Johnson, LL | |
dc.contributor.author | Houston, TA | |
dc.date.accessioned | 2017-05-03T13:55:45Z | |
dc.date.available | 2017-05-03T13:55:45Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 0040-4039 | |
dc.identifier.doi | 10.1016/S0040-4039(02)02196-2 | |
dc.identifier.uri | http://hdl.handle.net/10072/7014 | |
dc.description.abstract | Boronic acids were tethered to iminosugars in compounds such as 8 and 13 in order to increase their affinity for cell surfaces where glycoprotein processing enzymes are operative. Surprisingly, this modification diminished a-mannosidase inhibition while increasing ߭galactosidase inhibitory activity (8: Ki=2.0ױ0-4 M versus E. coli ߭galactosidase). The presence of a boronate in 8 and 13 has a profound impact on the specificity of this inhibition. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Pergamon | |
dc.publisher.place | UK | |
dc.relation.ispartofpagefrom | 8905 | |
dc.relation.ispartofpageto | 8908 | |
dc.relation.ispartofedition | 2002 | |
dc.relation.ispartofjournal | Tetrahedron Letters | |
dc.relation.ispartofvolume | 43 | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Organic chemistry | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 3405 | |
dc.title | A drug targeting motif for glycosidase inhibitors: an iminosugar-boronate shows unexpectedly selective b-galactosidase inhibition | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2015-05-11T00:49:04Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Houston, Todd A. | |