11Ala and A Alleles of RUNX2 associated with BMD in Scottish women; interaction of RUNX2 alleles with weight.
Author(s)
Vaughan, Tanya
Reid, D.
Morrison, Nigel
Ralston, S.
Year published
2003
Metadata
Show full item recordAbstract
We previously reported the association of the RUNX2 A allele with increased bone mineral density (BMD) and protection against a common form of osteoporotic fracture within a Geelong population. To further decipher the role of the RUNX2 A allele we genotyped 992 women from a Scottish cohort. The A allele was associated with higher femoral neck (FN) BMD (p=0.035) within a postmenopausal subgroup of the population (n=312). When the postmenopausal group was segregated into thin/normal (BMI = 25 kg/m2) and overweight /obese (BMI > 25 kg/m2), within the BMI > 25 kg/m2 group (n=140) the RUNX2 A allele showed a stronger ...
View more >We previously reported the association of the RUNX2 A allele with increased bone mineral density (BMD) and protection against a common form of osteoporotic fracture within a Geelong population. To further decipher the role of the RUNX2 A allele we genotyped 992 women from a Scottish cohort. The A allele was associated with higher femoral neck (FN) BMD (p=0.035) within a postmenopausal subgroup of the population (n=312). When the postmenopausal group was segregated into thin/normal (BMI = 25 kg/m2) and overweight /obese (BMI > 25 kg/m2), within the BMI > 25 kg/m2 group (n=140) the RUNX2 A allele showed a stronger effect on FN BMD, with the A allele accounting for 6.8% of the variance of FN BMD. Significant differences in FN BMD were detected in both A allele carriers (GA and AA genotypes) and non-A allele carriers (GG genotype) when comparing thin/normal women to overweight/obese women. The 11Ala RUNX2 deletion allele was significantly associated with decreased lumbar spine (LS) BMD (p=0.018) within the BMI > 25 kg/m2 group (n=546) of the whole group. The 11Ala allele was significantly associated with increased levels of pyridinoline (p=0.014) and deoxypyridinoline (p=0.038) in the HRT treated subgroup of the population (n=492). Glutamine variants and an alanine insertion were identified within the group. These data suggest that the RUNX2 11Ala and A alleles exert differing affects on BMD showing preference for different skeletal sites.
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View more >We previously reported the association of the RUNX2 A allele with increased bone mineral density (BMD) and protection against a common form of osteoporotic fracture within a Geelong population. To further decipher the role of the RUNX2 A allele we genotyped 992 women from a Scottish cohort. The A allele was associated with higher femoral neck (FN) BMD (p=0.035) within a postmenopausal subgroup of the population (n=312). When the postmenopausal group was segregated into thin/normal (BMI = 25 kg/m2) and overweight /obese (BMI > 25 kg/m2), within the BMI > 25 kg/m2 group (n=140) the RUNX2 A allele showed a stronger effect on FN BMD, with the A allele accounting for 6.8% of the variance of FN BMD. Significant differences in FN BMD were detected in both A allele carriers (GA and AA genotypes) and non-A allele carriers (GG genotype) when comparing thin/normal women to overweight/obese women. The 11Ala RUNX2 deletion allele was significantly associated with decreased lumbar spine (LS) BMD (p=0.018) within the BMI > 25 kg/m2 group (n=546) of the whole group. The 11Ala allele was significantly associated with increased levels of pyridinoline (p=0.014) and deoxypyridinoline (p=0.038) in the HRT treated subgroup of the population (n=492). Glutamine variants and an alanine insertion were identified within the group. These data suggest that the RUNX2 11Ala and A alleles exert differing affects on BMD showing preference for different skeletal sites.
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Conference Title
Abstracts
Volume
35