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  • Clarithromycin and prednisolone inhibit cytokine production in chronic rhinosinusitis.

    Author(s)
    Wallwork, B
    Coman, W
    Feron, F
    Mackay-Sim, A
    Cervin, A
    Griffith University Author(s)
    Mackay-Sim, Alan
    Cervin, Anders U.
    Feron, Francois
    Wallwork, Ben
    Year published
    2002
    Metadata
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    Abstract
    Objectives: Long-term, low-dose macrolide therapy is effective in the treatment of chronic rhinosinusitis. The mechanism of its anti-inflammatory effect and how this differs from corticosteroids remains unclear. The effect of clarithromycin and prednisolone on interleukin-5, interleukin-8, and granulocyte-macrophage colony-stimulating factor production by cultured chronic sinusitis nasal mucosa was examined in the study. Study Design and Methods: Nasal mucosa was obtained from 11 patients with chronic sinusitis. This tissue was cultured for 24 hours in the presence of clarithromycin or prednisolone at a variety of ...
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    Objectives: Long-term, low-dose macrolide therapy is effective in the treatment of chronic rhinosinusitis. The mechanism of its anti-inflammatory effect and how this differs from corticosteroids remains unclear. The effect of clarithromycin and prednisolone on interleukin-5, interleukin-8, and granulocyte-macrophage colony-stimulating factor production by cultured chronic sinusitis nasal mucosa was examined in the study. Study Design and Methods: Nasal mucosa was obtained from 11 patients with chronic sinusitis. This tissue was cultured for 24 hours in the presence of clarithromycin or prednisolone at a variety of concentrations. Cytokine levels were determined by enzyme-linked immunoassay. Results: Clarithromycin and prednisolone each produced significant reductions in interleukin-5, interleukin-8, and granulocyte-macrophage colony-stimulating factor production. There was no significant difference between the effects of clarithromycin and prednisolone. Conclusion: Macrolide antibiotics are capable of inhibiting pro-inflammatory cytokine production in vitro and are as potent as prednisolone. This mechanism is likely to be at least partly responsible for the clinical efficacy of macrolide antibiotics in chronic rhinosinusitis.
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    Journal Title
    Laryngoscope
    Volume
    112
    Publisher URI
    http://www3.interscience.wiley.com/journal/121460873/home
    DOI
    https://doi.org/10.1097/00005537-200210000-00022
    Copyright Statement
    © 2002 Lippincott, Williams & Wilkins. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please use the hypertext link above to access the journal's website or contact the author for more information.
    Subject
    Clinical Sciences
    Publication URI
    http://hdl.handle.net/10072/7883
    Collection
    • Journal articles

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