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  • How Proton Translocation Across Mitochondrial Inner Membranes Drives The Rotation Of The Fo Rotor Of ATP Synthase

    Author(s)
    McCabe, Michael
    Bourgain, Renaat
    Maguire, David
    Griffith University Author(s)
    Maguire, David J.
    McCabe, Michael
    Year published
    2003
    Metadata
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    Abstract
    In 1997 Walker and Boyer shared the Nobel prize for Chemistry. Their great contribution was the elucidation of a mechanism for the F1 portion of ATP synthase 1. It is significant that despite advances in the areas of mitochondrial genetics and proteomics, there are still gaps in our understanding of the overall mechanism of ATP synthesis. Among such deficiencies in knowledge is the crucial but still obscure role of the Fo component of the system. We believe that an understanding of the mechanism whereby the Fo rotor is driven by the membrane proton gradient is still an outstanding priority in bioenergetics research. Any model ...
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    In 1997 Walker and Boyer shared the Nobel prize for Chemistry. Their great contribution was the elucidation of a mechanism for the F1 portion of ATP synthase 1. It is significant that despite advances in the areas of mitochondrial genetics and proteomics, there are still gaps in our understanding of the overall mechanism of ATP synthesis. Among such deficiencies in knowledge is the crucial but still obscure role of the Fo component of the system. We believe that an understanding of the mechanism whereby the Fo rotor is driven by the membrane proton gradient is still an outstanding priority in bioenergetics research. Any model which purports to explain the role of the Fo sector of ATP synthase must be sufficiently detailed to permit the precise thermodynamic or kinetic consequences of the model to be calculated. Yet the model should ideally be simple enough to contain a minimum, preferably zero, number of unproveable assumptions. We present a model herein, which we believe fulfils the required criteria.
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    Journal Title
    Advances in Experimental Medicine and Biology
    Volume
    540
    Publisher URI
    http://dx.doi.org/10.1007/978-1-4757-6125-2
    DOI
    https://doi.org/10.1007/978-1-4757-6125-2_19
    Subject
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/7896
    Collection
    • Journal articles

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