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  • Analysis of Physicochemical Properties for Drugs of Natural Origin

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    104168_1.pdf (459.5Kb)
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    Accepted Manuscript (AM)
    Author(s)
    Camp, David
    Garavelas, Agatha
    Campitelli, Marc
    Griffith University Author(s)
    Camp, David B.
    Garavelas, Agatha
    Campitelli, Marc R.
    Year published
    2015
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    Abstract
    The impact of time, therapy area, and route of administration on 13 physicochemical properties calculated for 664 drugs developed from a natural prototype was investigated. The mean values for the majority of properties sampled over five periods from pre-1900 to 2013 were found to change in a statistically significant manner. In contrast, lipophilicity and aromatic ring count remained relatively constant, suggesting that these parameters are the most important for successful prosecution of a natural product drug discovery program if the route of administration is not focused exclusively on oral availability. An examination ...
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    The impact of time, therapy area, and route of administration on 13 physicochemical properties calculated for 664 drugs developed from a natural prototype was investigated. The mean values for the majority of properties sampled over five periods from pre-1900 to 2013 were found to change in a statistically significant manner. In contrast, lipophilicity and aromatic ring count remained relatively constant, suggesting that these parameters are the most important for successful prosecution of a natural product drug discovery program if the route of administration is not focused exclusively on oral availability. An examination by therapy area revealed that anti-infective agents had the most differences in physicochemical property profiles compared with other areas, particularly with respect to lipophilicity. However, when this group was removed, the variation between the mean values for lipophilicity and aromatic ring count across the remaining therapy areas was again found not to change in a meaningful manner, further highlighting the importance of these two parameters. The vast majority of drugs with a natural progenitor were formulated for either oral and/or injectable administration. Injectables were, on average, larger and more polar than drugs developed for oral, topical, and inhalation routes.
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    Journal Title
    Journal of Natural Products
    Volume
    78
    DOI
    https://doi.org/10.1021/acs.jnatprod.5b00255
    Copyright Statement
    This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Natural Products, copyright 2015 American Chemical Society and the American Society of Pharmacognosy after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.jnatprod.5b00255.
    Subject
    Chemical sciences
    Cheminformatics and quantitative structure-activity relationships
    Biological sciences
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/79987
    Collection
    • Journal articles

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