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dc.contributor.authorMorris, Norman
dc.contributor.authorBeck, K.
dc.contributor.authorSnyder, E.
dc.contributor.authorOslon, T.
dc.contributor.authorOlson, L.
dc.contributor.authorJohnson, B.
dc.date.accessioned2017-05-03T13:27:57Z
dc.date.available2017-05-03T13:27:57Z
dc.date.issued2005
dc.date.modified2007-03-12T08:19:10Z
dc.identifier.urihttp://hdl.handle.net/10072/9787
dc.description.abstractBody: The factors that predict exercise capacity in CHF are not well understood. It is clear the systolic factors such as ejection fraction (EF) are poor predictors of exercise capacity (VO2peak) in CHF. Recently some studies have suggested that other cardiovascular factors such as diastolic function and left ventricular stiffness may be better predictors of VO2peak. We have recently developed a method of measuring lung-to-lung circulation time (circ time) using the reappearance of end tidal acetylene (PetC2H2) in the expired air following a single inhalation. This measure of circ time is not only dependent on cardiac function but also on blood flow distribution and thus may provide additional information on the cardiovascular impairment to exercise in CHF. We hypothesized that resting circ time may be a predictor of VO2peak in CHF, with longer resting circ times indicating poorer exercise capacity. Twenty-one CHF patients (age 58Რyr, NYHA = 1.9ᰮ2; EF = 27.5Ხ0 %, meanᓅM) participated in the study. Exercise capacity was determined using an incremental treadmill test, while resting circ time was measured using acetylene inhalation. The mean peak exercise capacity (VO2peak) for the CHF patients was 18.7ᱮ1 ml.kg-1.min-1 and the resting circ time was 53.7ᱮ8 s. Peak exercise capacity was strongly correlated with resting circ time (r=-0.74, P<0.01) and poorly correlated with EF (r=0.11, p=ns). These results suggest that the measurement of resting lung-to-lung circulation time may be a better predictor of exercise capacity in CHF than more traditional cardiovascular measures of systolic function.
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeFrance
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofconferencenameHeart Failure Society of America Annual General Meeting
dc.relation.ispartofconferencetitleJournal of Cardiac Failure (11) 6
dc.relation.ispartofdatefrom2005-09-18
dc.relation.ispartofdateto2005-09-21
dc.relation.ispartoflocationBoca Raton, Florida, USA
dc.rights.retentionY
dc.subject.fieldofresearchcode270604
dc.titleResting cirulation time as a predictor of exercise capacity in heart failure patients
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dc.type.codeE - Conference Publications
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorMorris, Norman


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    Contains papers delivered by Griffith authors at national and international conferences.

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