• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Conference outputs
    • View Item
    • Home
    • Griffith Research Online
    • Conference outputs
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Multipotent cells from adult olfactory mucosa and their utility for tissue repair

    Author(s)
    Murrell, W
    Feron, F
    Wetzig, A
    Cameron, N
    Splatt, K
    Bellette, B
    Bianco, J
    Perry, C
    Lee, G
    Mackay-Sim, A
    Griffith University Author(s)
    Cameron, Nicholas
    Mackay-Sim, Alan
    Murrell, Wayne G.
    Bianco, John I.
    Wetzig, Andrew R.
    Perry, Christopher
    Splatt, Karisha J.
    Feron, Francois
    Bellette, Bernadette
    Year published
    2005
    Metadata
    Show full item record
    Abstract
    Multipotent stem cells are thought to be responsible for the generation of new neurons in the adult brain. Neurogenesis also occurs in an accessible part of the nervous system, the olfactory mucosa. We show here that cells from human olfactory mucosa generate neurospheres that are multipotent in vitro and when transplanted into the chicken embryo. Cloned neurosphere cells show this multipotency. Multipotency was evident without prior culture in vitro: cells dissociated from adult rat olfactory mucosa generate leukocytes when transplanted into bone-marrow irradiated hosts and cells dissociated from adult mouse olfactory ...
    View more >
    Multipotent stem cells are thought to be responsible for the generation of new neurons in the adult brain. Neurogenesis also occurs in an accessible part of the nervous system, the olfactory mucosa. We show here that cells from human olfactory mucosa generate neurospheres that are multipotent in vitro and when transplanted into the chicken embryo. Cloned neurosphere cells show this multipotency. Multipotency was evident without prior culture in vitro: cells dissociated from adult rat olfactory mucosa generate leukocytes when transplanted into bone-marrow irradiated hosts and cells dissociated from adult mouse olfactory epithelium generated numerous cell types when transplanted into the chicken embryo. It is unlikely that these results can be attributed to hematopoietic precursor contamination or cell fusion. These results demonstrate the existence of a multipotent stem-like cell in the olfactory mucosa useful for autologous transplantation therapies and for cellular studies of disease. To date we have instigated two tissue repair strategies using olfactory stem cells and here report data generated from two pilot studies: those of a rat model of Parkinson's disease and of a rat model of cardiac infarct.
    View less >
    Conference Title
    MECHANISMS OF DEVELOPMENT
    Volume
    122
    Publisher URI
    http://www.sciencedirect.com/science/journal/09254773
    DOI
    https://doi.org/10.1016/j.mod.2005.06.010
    Subject
    Biological Sciences
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/9857
    Collection
    • Conference outputs

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander