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dc.contributor.convenor!5th International Society of Developmental Biologistsen_AU
dc.contributor.authorMurrell, Wayneen_US
dc.contributor.authorWetzig, Andrewen_US
dc.contributor.authorSplatt, Karishaen_US
dc.contributor.authorBianco, Johnen_US
dc.contributor.authorLee, Gabrielen_US
dc.contributor.authorMackay-Sim, Alanen_US
dc.contributor.editorPatrick Tamen_US
dc.description.abstractMultipotent stem cells are thought to be responsible for the generation of new neurons in the adult brain. Neurogenesis also occurs in an accessible part of the nervous system, the olfactory mucosa. We show here that cells from human olfactory mucosa generate neurospheres that are multipotent in vitro and when transplanted into the chicken embryo. Cloned neurosphere cells show this multipotency. Multipotency was evident without prior culture in vitro: cells dissociated from adult rat olfactory mucosa generate leukocytes when transplanted into bone-marrow irradiated hosts and cells dissociated from adult mouse olfactory epithelium generated numerous cell types when transplanted into the chicken embryo. It is unlikely that these results can be attributed to hematopoietic precursor contamination or cell fusion. These results demonstrate the existence of a multipotent stem-like cell in the olfactory mucosa useful for autologous transplantation therapies and for cellular studies of disease. To date we have instigated two tissue repair strategies using olfactory stem cells and here report data generated from two pilot studies: those of a rat model of Parkinson's disease and of a rat model of cardiac infarct.en_US
dc.publisher.placeAmsterdam, The Netherlandsen_US
dc.relation.ispartofconferencename15th International Society of Developmental Biologists Congress 2005en_US
dc.relation.ispartofconferencetitleMechanisms of Developmenten_US
dc.titleMultipotent cells from adult olfactory mucosa and their utility for tissue repairen_US
dc.typeConference outputen_US
dc.type.descriptionE3 - Conference Publications (Extract Paper)en_US
dc.type.codeE - Conference Publicationsen_US
gro.hasfulltextNo Full Text

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    Contains papers delivered by Griffith authors at national and international conferences.

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