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dc.contributor.convenor!5th International Society of Developmental Biologists
dc.contributor.authorMurrell, W
dc.contributor.authorFeron, F
dc.contributor.authorWetzig, A
dc.contributor.authorCameron, N
dc.contributor.authorSplatt, K
dc.contributor.authorBellette, B
dc.contributor.authorBianco, J
dc.contributor.authorPerry, C
dc.contributor.authorLee, G
dc.contributor.authorMackay-Sim, A
dc.contributor.editorPatrick Tam
dc.date.accessioned2017-05-03T12:01:31Z
dc.date.available2017-05-03T12:01:31Z
dc.date.issued2005
dc.date.modified2011-07-01T06:57:04Z
dc.identifier.issn0925-4773
dc.identifier.doi10.1016/j.mod.2005.06.010
dc.identifier.urihttp://hdl.handle.net/10072/9857
dc.description.abstractMultipotent stem cells are thought to be responsible for the generation of new neurons in the adult brain. Neurogenesis also occurs in an accessible part of the nervous system, the olfactory mucosa. We show here that cells from human olfactory mucosa generate neurospheres that are multipotent in vitro and when transplanted into the chicken embryo. Cloned neurosphere cells show this multipotency. Multipotency was evident without prior culture in vitro: cells dissociated from adult rat olfactory mucosa generate leukocytes when transplanted into bone-marrow irradiated hosts and cells dissociated from adult mouse olfactory epithelium generated numerous cell types when transplanted into the chicken embryo. It is unlikely that these results can be attributed to hematopoietic precursor contamination or cell fusion. These results demonstrate the existence of a multipotent stem-like cell in the olfactory mucosa useful for autologous transplantation therapies and for cellular studies of disease. To date we have instigated two tissue repair strategies using olfactory stem cells and here report data generated from two pilot studies: those of a rat model of Parkinson's disease and of a rat model of cardiac infarct.
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeAmsterdam, The Netherlands
dc.publisher.urihttp://www.sciencedirect.com/science/journal/09254773
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofconferencename15th International Society of Developmental Biologists Congress 2005
dc.relation.ispartofconferencetitleMECHANISMS OF DEVELOPMENT
dc.relation.ispartofdatefrom2005-09-03
dc.relation.ispartofdateto2005-09-07
dc.relation.ispartoflocationSydney
dc.relation.ispartofpagefromS135
dc.relation.ispartofpagefrom2 pages
dc.relation.ispartofpagetoS136
dc.relation.ispartofpageto2 pages
dc.relation.ispartofvolume122
dc.rights.retentionY
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titleMultipotent cells from adult olfactory mucosa and their utility for tissue repair
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dc.type.codeE - Conference Publications
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorCameron, Nicholas
gro.griffith.authorMackay-Sim, Alan
gro.griffith.authorMurrell, Wayne G.
gro.griffith.authorBianco, John I.
gro.griffith.authorWetzig, Andrew R.
gro.griffith.authorPerry, Christopher
gro.griffith.authorSplatt, Karisha J.
gro.griffith.authorFeron, Francois
gro.griffith.authorBellette, Bernadette


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    Contains papers delivered by Griffith authors at national and international conferences.

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