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  • Urinary tract infection of mice to model human disease: Practicalities, implications and limitations

    Author(s)
    Carey, Alison J
    Tan, Chee K
    Ipe, Deepak S
    Sullivan, Matthew J
    Cripps, Allan W
    Schembri, Mark A
    Ulett, Glen C
    Griffith University Author(s)
    Cripps, Allan W.
    Ulett, Glen C.
    Ipe, Deepak S.
    Tan, CK K.
    Carey, Alison
    Sullivan, Matthew J.
    Year published
    2016
    Metadata
    Show full item record
    Abstract
    Urinary tract infections (UTIs) are among the most common bacterial infections in humans. Murine models of human UTI are vital experimental tools that have helped to elucidate UTI pathogenesis and advance knowledge of potential treatment and infection prevention strategies. Fundamentally, several variables are inherent in different murine models, and understanding the limitations of these variables provides an opportunity to understand how models may be best applied to research aimed at mimicking human disease. In this review, we discuss variables inherent in murine UTI model studies and how these affect model usage, data ...
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    Urinary tract infections (UTIs) are among the most common bacterial infections in humans. Murine models of human UTI are vital experimental tools that have helped to elucidate UTI pathogenesis and advance knowledge of potential treatment and infection prevention strategies. Fundamentally, several variables are inherent in different murine models, and understanding the limitations of these variables provides an opportunity to understand how models may be best applied to research aimed at mimicking human disease. In this review, we discuss variables inherent in murine UTI model studies and how these affect model usage, data analysis and data interpretation. We examine recent studies that have elucidated UTI host–pathogen interactions from the perspective of gene expression, and review new studies of biofilm and UTI preventative approaches. We also consider potential standards for variables inherent in murine UTI models and discuss how these might expand the utility of models for mimicking human disease and uncovering new aspects of pathogenesis.
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    Journal Title
    Critical Reviews in Microbiology
    DOI
    https://doi.org/10.3109/1040841X.2015.1028885
    Note
    This publication has been entered into Griffith Research Online as an Advanced Online Version.
    Subject
    Medical Bacteriology
    Microbiology
    Medical Microbiology
    Publication URI
    http://hdl.handle.net/10072/98973
    Collection
    • Journal articles

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