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dc.contributor.authorCarey, Alison J
dc.contributor.authorTan, Chee K
dc.contributor.authorIpe, Deepak S
dc.contributor.authorSullivan, Matthew J
dc.contributor.authorCripps, Allan W
dc.contributor.authorSchembri, Mark A
dc.contributor.authorUlett, Glen C
dc.description.abstractUrinary tract infections (UTIs) are among the most common bacterial infections in humans. Murine models of human UTI are vital experimental tools that have helped to elucidate UTI pathogenesis and advance knowledge of potential treatment and infection prevention strategies. Fundamentally, several variables are inherent in different murine models, and understanding the limitations of these variables provides an opportunity to understand how models may be best applied to research aimed at mimicking human disease. In this review, we discuss variables inherent in murine UTI model studies and how these affect model usage, data analysis and data interpretation. We examine recent studies that have elucidated UTI host–pathogen interactions from the perspective of gene expression, and review new studies of biofilm and UTI preventative approaches. We also consider potential standards for variables inherent in murine UTI models and discuss how these might expand the utility of models for mimicking human disease and uncovering new aspects of pathogenesis.
dc.publisherTaylor & Francis
dc.relation.ispartofjournalCritical Reviews in Microbiology
dc.subject.fieldofresearchMedical Bacteriology
dc.subject.fieldofresearchMedical Microbiology
dc.titleUrinary tract infection of mice to model human disease: Practicalities, implications and limitations
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.hasfulltextNo Full Text
gro.griffith.authorCripps, Allan W.
gro.griffith.authorUlett, Glen C.
gro.griffith.authorIpe, Deepak S.
gro.griffith.authorTan, CK K.
gro.griffith.authorCarey, Alison
gro.griffith.authorSullivan, Matthew J.

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