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dc.contributor.authorHuth, TK
dc.contributor.authorBrenu, EW
dc.contributor.authorRamos, S
dc.contributor.authorNguyen, T
dc.contributor.authorBroadley, S
dc.contributor.authorStaines, D
dc.contributor.authorMarshall-Gradisnik, S
dc.date.accessioned2018-03-01T12:30:18Z
dc.date.available2018-03-01T12:30:18Z
dc.date.issued2016
dc.identifier.issn0300-9475
dc.identifier.doi10.1111/sji.12388
dc.identifier.urihttp://hdl.handle.net/10072/98997
dc.description.abstractPatients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and multiple sclerosis (MS) suffer from debilitating fatigue which is not alleviated by rest. In addition to the fatigue-related symptoms suffered by patients with CFS/ME and MS, dysfunction of the immune system and, in particular, reduced natural killer (NK) cell cytotoxic activity has also been reported in CFS/ME and MS. The purpose of this pilot study was to compare NK cellular mechanisms in patients with CFS/ME and MS to investigate potential dysfunctions in the NK cell activity pathway. Flow cytometry protocols assessed CD56dimCD16+ and CD56brightCD16+/− NK cell expression of adhesion molecules, NK activating and inhibiting receptors, NK cell maturation and lytic proteins. All participants in this study were female and included 14 patients with CFS/ME, nine patients with MS and 19 non-fatigued controls. The patient groups and the non-fatigued controls were not taking any immunosuppressive or immune-enhancing medications. In the MS cohort, KIR2DL5 was significantly increased on CD56brightCD16+/− NK cells and expression of CD94 was significantly increased on CD56dimCD16+ NK cells in comparison with the controls. Co-expression of CD57 and perforin was significantly increased on CD56dimCD16+ NK cells from patients with CFS/ME compared to the MS and non-fatigued control participants. The results from this pilot study suggest that NK cells from patients with CFS/ME and MS may have undergone increased differentiation in response to external stimuli which may affect different mechanisms in the NK cell cytotoxic activity pathway.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing Ltd.
dc.relation.ispartofpagefrom44
dc.relation.ispartofpageto51
dc.relation.ispartofissue1
dc.relation.ispartofjournalScandinavian Journal of Immunology
dc.relation.ispartofvolume83
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchCellular immunology
dc.subject.fieldofresearchcode3204
dc.subject.fieldofresearchcode320404
dc.titlePilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyright© 2016 The Authors. Scandinavian Journal of Immunology published by John Wiley & Sons Ltd on behalf of The Foundation for the Scandinavian Journal of Immunology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
gro.hasfulltextFull Text
gro.griffith.authorStaines, Donald R.
gro.griffith.authorBroadley, Simon
gro.griffith.authorHuth, Teilah K.
gro.griffith.authorRamos, Sandra B.
gro.griffith.authorMarshall-Gradisnik, Sonya M.
gro.griffith.authorBrenu, Ekua
gro.griffith.authorNguyen, Thao


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