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dc.contributor.authorBrousseau, Nicholas
dc.contributor.authorAndrews, Nick
dc.contributor.authorWaight, Pauline
dc.contributor.authorStanford, Elaine
dc.contributor.authorNewton, Emma
dc.contributor.authorAlmond, Rachael
dc.contributor.authorSlack, Mary PE
dc.contributor.authorMiller, Elizabeth
dc.contributor.authorBorrow, Ray
dc.contributor.authorLadhani, Shamez N
dc.date.accessioned2018-05-08T03:33:03Z
dc.date.available2018-05-08T03:33:03Z
dc.date.issued2015
dc.identifier.issn1058-4838
dc.identifier.doi10.1093/cid/civ164
dc.identifier.urihttp://hdl.handle.net/10072/99008
dc.description.abstractBackground. This study aimed to estimate, following invasive pneumococcal disease (IPD), the proportion of children with protective immunoglobulin G (IgG) concentrations against the infecting serotype compared with other vaccine serotypes, and to assess risk of recurrent IPD. Methods. Pneumococcal antibody concentrations were available for 413 children with vaccine-type IPD diagnosed during 2006–2013. We compared serotype-specific IgG concentrations against the infecting vs other vaccine serotypes, after adjusting for confounders such as age using multilevel analyses. Results. After IPD, a higher proportion of vaccine-naive children had IgG concentrations ≥0.35 µg/mL against their infecting serotype than other vaccine serotypes (51% vs 36%; P < .001). In contrast, among children immunized with pneumococcal conjugate vaccine (PCV) both before and after IPD, the proportion with IgG concentrations ≥0.35 µg/mL against the infecting serotype was lower compared with other vaccine serotypes (71% vs 98%; P < .001). These children also had lower IgG geometric mean concentrations (GMCs) against the infecting serotype (2.22 µg/mL) vs other vaccine serotypes (15.64 µg/mL) in multilevel models (IgG GMC ratio, 0.24; 95% confidence interval, .18–.32), although their IgG GMC was higher compared with vaccine-naive children. Vaccinated children with IgG concentrations <0.35 µg/mL against their infecting serotype generally remained unresponsive despite further vaccine doses. However, recurrent IPD with the same infecting serotype was rare (7/3030 children [0.2%]) and not associated with unresponsiveness. Conclusions. Vaccination with PCV before and/or after IPD was associated with lower IgG concentrations against the infecting serotype compared with other vaccine serotypes, but recurrent IPD was rare. Further studies are needed to understand this phenomenon in immunized children.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofpagefrom1793
dc.relation.ispartofpageto1801
dc.relation.ispartofissue12
dc.relation.ispartofjournalClinical Infectious Diseases
dc.relation.ispartofvolume60
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchMedical virology
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320705
dc.titleAntibody concentrations against the infecting serotype in vaccinated and unvaccinated children with invasive pneumococcal disease in the United Kingdom, 2006-2013
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorSlack, Mary P.


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