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  • Could the biological robustness of low level laser therapy (Photobiomodulation) impact its use in the management of mucositis in head and neck cancer patients

    Author(s)
    Sonis, Stephen T.
    Hashemi, Sepehr
    Epstein, Joel B.
    Nair, Raj
    Raber-Durlacher, Judith E.
    Griffith University Author(s)
    Nair, Raj
    Year published
    2016
    Metadata
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    Abstract
    Low level laser therapy (LLLT) has been noted to be effective in mitigating the development of oral mucositis among patients being treated with chemoradiation for cancers of the head and neck. To explain the biological basis for this observation we performed a comprehensive literature search. Our investigation identified a substantial number of LLLT-activated pathways that have been strongly associated with negative tumor outcomes including proliferation, invasion, angiogenesis, metastases and cancer-treatment resistance. In light of these findings, we suggest an investigational strategy to assure that LLLT’s anti-mucositis ...
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    Low level laser therapy (LLLT) has been noted to be effective in mitigating the development of oral mucositis among patients being treated with chemoradiation for cancers of the head and neck. To explain the biological basis for this observation we performed a comprehensive literature search. Our investigation identified a substantial number of LLLT-activated pathways that have been strongly associated with negative tumor outcomes including proliferation, invasion, angiogenesis, metastases and cancer-treatment resistance. In light of these findings, we suggest an investigational strategy to assure that LLLT’s anti-mucositis efficacy is independent of its possible potential to enhance threatening tumor behaviors. Included are appropriate pre-clinical modeling, short- and long-term follow-up of LLLT-treated patients, and the requirement for consistency of LLLT parameters.
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    Journal Title
    Oral Oncology
    Volume
    54
    DOI
    https://doi.org/10.1016/j.oraloncology.2016.01.005
    Subject
    Dentistry
    Oncology and carcinogenesis
    Oncology and carcinogenesis not elsewhere classified
    Health services and systems
    Public health
    Publication URI
    http://hdl.handle.net/10072/99031
    Collection
    • Journal articles

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