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dc.contributor.authorSonis, Stephen T.
dc.contributor.authorHashemi, Sepehr
dc.contributor.authorEpstein, Joel B.
dc.contributor.authorNair, Raj
dc.contributor.authorRaber-Durlacher, Judith E.
dc.date.accessioned2018-07-20T00:16:00Z
dc.date.available2018-07-20T00:16:00Z
dc.date.issued2016
dc.identifier.issn1368-8375
dc.identifier.doi10.1016/j.oraloncology.2016.01.005
dc.identifier.urihttp://hdl.handle.net/10072/99031
dc.description.abstractLow level laser therapy (LLLT) has been noted to be effective in mitigating the development of oral mucositis among patients being treated with chemoradiation for cancers of the head and neck. To explain the biological basis for this observation we performed a comprehensive literature search. Our investigation identified a substantial number of LLLT-activated pathways that have been strongly associated with negative tumor outcomes including proliferation, invasion, angiogenesis, metastases and cancer-treatment resistance. In light of these findings, we suggest an investigational strategy to assure that LLLT’s anti-mucositis efficacy is independent of its possible potential to enhance threatening tumor behaviors. Included are appropriate pre-clinical modeling, short- and long-term follow-up of LLLT-treated patients, and the requirement for consistency of LLLT parameters.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom7
dc.relation.ispartofpageto14
dc.relation.ispartofjournalOral Oncology
dc.relation.ispartofvolume54
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchOncology and carcinogenesis not elsewhere classified
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode3203
dc.subject.fieldofresearchcode3211
dc.subject.fieldofresearchcode321199
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.titleCould the biological robustness of low level laser therapy (Photobiomodulation) impact its use in the management of mucositis in head and neck cancer patients
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorNair, Raj


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