dc.contributor.author | McKetin, Rebecca | |
dc.contributor.author | Dawe, Sharon | |
dc.contributor.author | Burns, Richard A | |
dc.contributor.author | Hides, Leanne | |
dc.contributor.author | Kavanagh, David J | |
dc.contributor.author | Teesson, Maree | |
dc.contributor.author | Young, Ross McD | |
dc.contributor.author | Voce, Alexandra | |
dc.contributor.author | Saunders, John B | |
dc.date.accessioned | 2018-03-19T01:30:24Z | |
dc.date.available | 2018-03-19T01:30:24Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0376-8716 | |
dc.identifier.doi | 10.1016/j.drugalcdep.2016.01.018 | |
dc.identifier.uri | http://hdl.handle.net/10072/99116 | |
dc.description.abstract | Background: Methamphetamine use can produce symptoms almost indistinguishable from schizophrenia. Distinguishing between the two conditions has been hampered by the lack of a validated symptom profile for methamphetamine-induced psychiatric symptoms. We use data from a longitudinal cohort study to examine the profile of psychiatric symptoms that are acutely exacerbated by methamphetamine use.
Methods: 164 methamphetamine users, who did not meet DSM-IV criteria for a lifetime primary psychotic disorder, were followed monthly for one year to assess the relationship between days of methamphetamine use and symptom severity on the 24-item Brief Psychiatric Rating Scale. Exacerbation of psychiatric symptoms with methamphetamine use was quantified using random coefficient models. The dimensions of symptom exacerbation were examined using principal axis factoring and a latent profile analysis.
Results: Symptoms exacerbated by methamphetamine loaded on three factors: positive psychotic symptoms (suspiciousness, unusual thought content, hallucinations, bizarre behavior); affective symptoms (depression, suicidality, guilt, hostility, somatic concern, self-neglect); and psychomotor symptoms (tension, excitement, distractibility, motor hyperactivity). Methamphetamine use did not significantly increase negative symptoms. Vulnerability to positive psychotic and affective symptom exacerbation was shared by 28% of participants, and this vulnerability aligned with a past year DSM-IV diagnosis of substance-induced psychosis (38% vs. 22%, χ2 (df1) = 3.66, p = 0.056).
Conclusion: Methamphetamine use produced a symptom profile comprised of positive psychotic and affective symptoms, which aligned with a diagnosis of substance-induced psychosis, with no evidence of a negative syndrome. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofpagefrom | 104 | |
dc.relation.ispartofpageto | 109 | |
dc.relation.ispartofjournal | Drug and Alcohol Dependence | |
dc.relation.ispartofvolume | 161 | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Psychology | |
dc.subject.fieldofresearch | Other psychology not elsewhere classified | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 52 | |
dc.subject.fieldofresearchcode | 529999 | |
dc.title | The profile of psychiatric symptoms exacerbated by methamphetamine use | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.description.version | Accepted Manuscript (AM) | |
gro.rights.copyright | © 2016 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Dawe, Sharon | |