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dc.contributor.authorKhzam, Nabil
dc.contributor.authorBailey, David
dc.contributor.authorYie, Helen S
dc.contributor.authorBakr, Mahmoud M
dc.date.accessioned2018-01-19T01:29:58Z
dc.date.available2018-01-19T01:29:58Z
dc.date.issued2016
dc.identifier.issn2090-6447
dc.identifier.doi10.1155/2016/1095927
dc.identifier.urihttp://hdl.handle.net/10072/99331
dc.description.abstractWe present a case of a 47-year-old male who suffered from GE around his lower anterior teeth as soon as he started treatment with Felodipine 400mg. We show that oral hygiene measures, antibiotics, and conventional periodontal treatment (scaling and root planing SRP) were all not sufficient to resolve the drug induced GE, which will persist and/or recur provided that systemic effect of the offending medication is still present. The condition immediately resolved after switching to a different medication. The mechanism of GE is complex and not fully understood yet. It is mainly due to overexpression of a number of growth factors due to high concentrations of calcium ions (Ca2+).This affects fibroblasts proliferation and DNA synthesis and leads to a heavy chronic inflammatory cell infiltrate. Our case was managed according to the suggested protocols in previous case studies. The unique features in our case were the immediate onset of the adverse effect after starting the medication and the absence of any underlying medical condition apart from high blood pressure. Improving the oral hygiene together with SRP and cessation of the medication resolves drug induced GE.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherHindawi Publishing
dc.relation.ispartofpagefrom1095927- 1
dc.relation.ispartofpageto1095927-6
dc.relation.ispartofjournalCase Reports in Dentistry
dc.relation.ispartofvolume2016
dc.subject.fieldofresearchDental therapeutics, pharmacology and toxicology
dc.subject.fieldofresearchOral medicine and pathology
dc.subject.fieldofresearchPeriodontics
dc.subject.fieldofresearchcode320303
dc.subject.fieldofresearchcode320307
dc.subject.fieldofresearchcode320310
dc.titleGingival Enlargement Induced by Felodipine Resolves with a Conventional Periodontal Treatment and Drug Modification
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2016 Nabil Khzam et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorBakr, Mahmoud


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