Epidermal growth factor and diabetes mellitus; friends or faux?

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Author(s)
Al-Ankily, Mahmoud M.
Shamel, Mohamed
Bakr, Mahmoud
Griffith University Author(s)
Year published
2016
Metadata
Show full item recordAbstract
Diabetes being the most common chronic metabolic disorder has a
number of complications that affect various parts of the body.
Epidermal growth factor (EGF) is well known for its healing capacity.
In this article we review the two way relationship between diabetes
and EGF, where the former needs to block the latter’s secretion and
reduce its expression on order to produce its notorious
complications. On the contrary, the latter is capable of reversing the
former’s negative adverse effect on various organs of the body. We
also shed some light on different studies in the literature that
investigated the role of EGF in the ...
View more >Diabetes being the most common chronic metabolic disorder has a number of complications that affect various parts of the body. Epidermal growth factor (EGF) is well known for its healing capacity. In this article we review the two way relationship between diabetes and EGF, where the former needs to block the latter’s secretion and reduce its expression on order to produce its notorious complications. On the contrary, the latter is capable of reversing the former’s negative adverse effect on various organs of the body. We also shed some light on different studies in the literature that investigated the role of EGF in the dynamics of diabetes, and gain a deeper insight towards the possible applications of local and systemic treatment with EGF in the management of diabetic complications. We also try to answer some questions: EGF and diabetes; Friends or faux? and will EGF be the future trend in reversing damage caused by diabetes and wound healing? Key words: Submandibular salivary gland, epidermal growth factor, diabetes, streptozotocin, wound healing
View less >
View more >Diabetes being the most common chronic metabolic disorder has a number of complications that affect various parts of the body. Epidermal growth factor (EGF) is well known for its healing capacity. In this article we review the two way relationship between diabetes and EGF, where the former needs to block the latter’s secretion and reduce its expression on order to produce its notorious complications. On the contrary, the latter is capable of reversing the former’s negative adverse effect on various organs of the body. We also shed some light on different studies in the literature that investigated the role of EGF in the dynamics of diabetes, and gain a deeper insight towards the possible applications of local and systemic treatment with EGF in the management of diabetic complications. We also try to answer some questions: EGF and diabetes; Friends or faux? and will EGF be the future trend in reversing damage caused by diabetes and wound healing? Key words: Submandibular salivary gland, epidermal growth factor, diabetes, streptozotocin, wound healing
View less >
Journal Title
International Journal of Medical and Dental Sciences
Volume
5
Issue
2
Copyright Statement
© 2016 International journal of Medical and Dental Sciences (IJMDS). The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Subject
Dental Therapeutics, Pharmacology and Toxicology
Oral Medicine and Pathology