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dc.contributor.authorAitken, Leanne M
dc.contributor.authorBucknall, Tracey
dc.contributor.authorKent, Bridie
dc.contributor.authorMitchell, Marion
dc.contributor.authorBurmeister, Elizabeth
dc.contributor.authorKeogh, Samantha
dc.date.accessioned2018-01-10T23:03:12Z
dc.date.available2018-01-10T23:03:12Z
dc.date.issued2016
dc.identifier.issn0309-2402
dc.identifier.doi10.1111/jan.12843
dc.identifier.urihttp://hdl.handle.net/10072/99571
dc.description.abstractAims Assess the effects of protocol-directed sedation management on the duration of mechanical ventilation and other relevant patient outcomes in mechanically ventilated intensive care unit patients. Background Sedation is a core component of critical care. Sub-optimal sedation management incorporates both under- and over-sedation and has been linked to poorer patient outcomes. Design Cochrane systematic review of randomized controlled trials. Data sources Cochrane Central Register of Controlled trials, MEDLINE, EMBASE, CINAHL, Database of Abstracts of Reviews of Effects, LILACS, Current Controlled Trials and US National Institutes of Health Clinical Research Studies (1990–November 2013) and reference lists of articles were used. Review methods Randomized controlled trials conducted in intensive care units comparing management with and without protocol-directed sedation were included. Two authors screened titles, abstracts and full-text reports. Potential risk of bias was assessed. Clinical, methodological and statistical heterogeneity were examined and the random-effects model used for meta-analysis where appropriate. Mean difference for duration of mechanical ventilation and risk ratio for mortality, with 95% confidence intervals, were calculated. Results Two eligible studies with 633 participants comparing protocol-directed sedation delivered by nurses vs. usual care were identified. There was no evidence of differences in duration of mechanical ventilation or hospital mortality. There was statistically significant heterogeneity between studies for duration of mechanical ventilation. Conclusions There is insufficient evidence to evaluate the effectiveness of protocol-directed sedation as results from the two randomized controlled trials were conflicting.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing
dc.relation.ispartofpagefrom261
dc.relation.ispartofpageto272
dc.relation.ispartofissue2
dc.relation.ispartofjournalJournal of Advanced Nursing
dc.relation.ispartofvolume72
dc.subject.fieldofresearchNursing
dc.subject.fieldofresearchAcute care
dc.subject.fieldofresearchcode4205
dc.subject.fieldofresearchcode420501
dc.titleSedation protocols to reduce duration of mechanical ventilation in the ICU: a Cochrane Systematic Review
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyrightCopyright 2016 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Sedation protocols to reduce duration of mechanical ventilation in the ICU: a Cochrane Systematic Review, Journal of Advanced Nursing, 27(2)261-272, 2016, which has been published in final form at DOI. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
gro.hasfulltextFull Text
gro.griffith.authorMitchell, Marion L.


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