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dc.contributor.authorRaffield, Laura M
dc.contributor.authorCox, Amanda J
dc.contributor.authorFreedman, Barry I
dc.contributor.authorHugenschmidt, Christina E
dc.contributor.authorHsu, Fang-Chi
dc.contributor.authorWagner, Benjamin C
dc.contributor.authorXu, Jianzhao
dc.contributor.authorMaldjian, Joseph A
dc.contributor.authorBowden, Donald W
dc.date.accessioned2018-10-03T02:32:03Z
dc.date.available2018-10-03T02:32:03Z
dc.date.issued2016
dc.identifier.issn0940-5429
dc.identifier.doi10.1007/s00592-015-0815-z
dc.identifier.urihttp://hdl.handle.net/10072/99751
dc.description.abstractAims: To examine the relationships between type 2 diabetes (T2D) status, glycemic control, and T2D duration with magnetic resonance imaging (MRI)-derived neuroimaging measures in European Americans from the Diabetes Heart Study (DHS) Mind cohort. Methods: Relationships were examined using marginal models with generalized estimating equations in 784 participants from 514 DHS Mind families. Fasting plasma glucose, glycated hemoglobin, and diabetes duration were analyzed in 682 participants with T2D. Models were adjusted for potential confounders, including age, sex, history of cardiovascular disease, smoking, educational attainment, and use of statins or blood pressure medications. Association was tested with gray and white matter volume, white matter lesion volume, gray matter cerebral blood flow, and white and gray matter fractional anisotropy and mean diffusivity. Results: Adjusting for multiple comparisons, T2D status was associated with reduced white matter volume (p = 2.48 × 10−6) and reduced gray and white matter fractional anisotropy (p ≤ 0.001) in fully adjusted models, with a trend toward increased white matter lesion volume (p = 0.008) and increased gray and white matter mean diffusivity (p ≤ 0.031). Among T2D-affected participants, neither fasting glucose, glycated hemoglobin, nor diabetes duration were associated with the neuroimaging measures assessed (p > 0.05). Conclusions: While T2D was significantly associated with MRI-derived neuroimaging measures, differences in glycemic control in T2D-affected individuals in the DHS Mind study do not appear to significantly contribute to variation in these measures. This supports the idea that the presence or absence of T2D, not fine gradations of glycemic control, may be more significantly associated with age-related changes in the brain.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofpagefrom439
dc.relation.ispartofpageto447
dc.relation.ispartofissue3
dc.relation.ispartofjournalActa Diabetologica
dc.relation.ispartofvolume53
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchClinical sciences not elsewhere classified
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode320299
dc.titleAnalysis of the relationships between type 2 diabetes status, glycemic control, and neuroimaging measures in the Diabetes Heart Study Mind
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2016 Springer Milan. This is an electronic version of an article published in Acta Diabetologica, 2016, Volume 53, Issue 3, pp 439–447. Acta Diabetologica is available online at: http://link.springer.com/ with the open URL of your article.
gro.hasfulltextFull Text
gro.griffith.authorCox, Amanda J.


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