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dc.contributor.authorMamoori, Afraa
dc.contributor.authorGopalan, Vinod
dc.contributor.authorSmith, Robert Anthony
dc.contributor.authorLam, Alfred King-Yin
dc.date.accessioned2018-07-27T03:30:51Z
dc.date.available2018-07-27T03:30:51Z
dc.date.issued2016
dc.identifier.issn0248-4900
dc.identifier.doi10.1111/boc.201500062
dc.identifier.urihttp://hdl.handle.net/10072/99832
dc.description.abstractThere are emerging data to suggest that microRNAs (miRNAs) have significant roles in regulating the function of normal cells and cancer stem cells (CSCs). This review aims to analyse the roles of miRNAs in the regulation of colon CSCs through their interaction with various signalling pathways. Studies showed a large number of miRNAs that are reported to be deregulated in colon CSCs. However, few of the studies available were able to outline the function of miRNAs in colon CSCs and uncover their signalling pathways. From those miRNAs, which are better described, miR‐21 followed by miR‐34, miR‐200 and miR‐215 are the most reported miRNAs to have roles in colon CSC regulation. In particular, miRNAs have been reported to regulate the stemness features of colon CSCs mainly via Wnt/B‐catenin and Notch signalling pathways. Additionally, miRNAs have been reported to act on processes involving CSCs through cell cycle regulation genes and epithelial–mesenchymal transition. The relative paucity of data available on the significance of miRNAs in CSCs means that new studies will be of great importance to determine their roles and to identify the signalling pathways through which they operate. Such studies may in future guide further research to target these genes for more effective cancer treatment. miRNAs were shown to regulate the function of cancer stem cells in large bowel cancer by targeting a few key signalling pathways in cells.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.relation.ispartofpagefrom51
dc.relation.ispartofpageto64
dc.relation.ispartofissue3
dc.relation.ispartofjournalBiology of the Cell
dc.relation.ispartofvolume108
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchOther biological sciences not elsewhere classified
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode319999
dc.titleModulatory roles of microRNAs in the regulation of different signalling pathways in large bowel cancer stem cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorLam, Alfred K.
gro.griffith.authorGopalan, Vinod


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