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dc.contributor.authorChan, Amy
dc.contributor.authorHussein, Waleed M
dc.contributor.authorGhaffar, Khairunnisa Abdul
dc.contributor.authorMarasini, Nirmal
dc.contributor.authorMostafa, Ahmed
dc.contributor.authorEskandari, Sharareh
dc.contributor.authorBatzloff, Michael R
dc.contributor.authorGood, Michael F
dc.contributor.authorSkwarczynski, Mariusz
dc.contributor.authorToth, Istvan
dc.date.accessioned2018-06-15T07:38:52Z
dc.date.available2018-06-15T07:38:52Z
dc.date.issued2016
dc.identifier.issn0968-0896
dc.identifier.doi10.1016/j.bmc.2016.03.063
dc.identifier.urihttp://hdl.handle.net/10072/99833
dc.description.abstractInfection with Group A Streptococcus (GAS) can result in a range of different illnesses, some of which are fatal. Currently, our efforts to develop a vaccine against GAS focuses on the lipid core peptide (LCP) system, a subunit vaccine containing a lipoamino acid (LAA) moiety which allows the stimulation of systemic antibody activity. In the present study, a peptide (J14) representing the B-cell epitope from the GAS M protein was incorporated alongside a universal T-helper epitope (P25) in four LCP constructs of different spatial orientation or LAA lengths. Through structure–activity studies, it was discovered that while the alteration of the LCP orientation had a weaker effect on immunostimulation, increasing the LAA side chain length within the construct increased antibody responses in murine models. Furthermore, the mice immunised with the lead LCP construct were also able to maintain antibody activity throughout the course of five months. These findings highlight the importance of LAA moieties in the development of intranasal peptide vaccines and confirmed that its side chain length has an effect on the immunogenicity of the structure.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPergamon
dc.relation.ispartofpagefrom3095
dc.relation.ispartofpageto3101
dc.relation.ispartofissue14
dc.relation.ispartofjournalBioorganic & Medicinal Chemistry
dc.relation.ispartofvolume24
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchBiochemistry and cell biology not elsewhere classified
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode310199
dc.subject.fieldofresearchcode3214
dc.subject.fieldofresearchcode3101
dc.titleStructure-activity relationship of lipid core peptide-based Group A Streptococcus vaccine candidates
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorGood, Michael F.
gro.griffith.authorEskandari, Sherry


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