Synthesis of lactose-based S-linked sialylmimetics of alpha(2,3)-sialosides.

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Liakatos, A
Kiefel, MJ
von Itzstein, M
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Amos B Smith, Carol Carr
Date
2003
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Abstract

A new approach toward the synthesis of lactose-based S-linked sialylmimetics of a(2,3)-linked sialosides is described. These compounds, represented by the general structure 3, were prepared from methyl ߭d-lactoside in 11 steps. It was found that the choice of protecting group was crucial to allow the efficient introduction of sulfur at the 3-position of the galactose ring.

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Organic Letters
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5
Issue
23
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© 2003 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author for more information.
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Chemical sciences
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