Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp.
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Moriou, Celine
Petek, Sylvain
Fauchon, Marilyne
Hellio, Claire
Saulnier, Denis
Ekins, Merrick
Hooper, John NA
Al-Mourabit, Ali
Debitus, Cecile
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Abstract
Four new brominated tyrosine metabolites, aplyzanzines C–F (1–4), were isolated from the French Polynesian sponge Pseudoceratina n. sp., along with the two known 2-aminoimidazolic derivatives, purealidin A (5) and 6, previously isolated, respectively, from the sponges Psammaplysilla purpurea and Verongula sp. Their structures were assigned based on the interpretation of their NMR and HRMS data. The compounds exhibited quorum sensing inhibition (QSi) and antifouling activities against several strains of bacteria and microalgae. To our knowledge, the QSi activity of this type of bromotyrosine metabolite is described here for the first time.
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Marine drugs
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18
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5
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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Physical chemistry
Pharmacology and pharmaceutical sciences
Science & Technology
Life Sciences & Biomedicine
Chemistry, Medicinal
sponge
Pharmacy
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Tintillier, F; Moriou, C; Petek, S; Fauchon, M; Hellio, C; Saulnier, D; Ekins, M; Hooper, JNA; Al-Mourabit, A; Debitus, C, Quorum Sensing Inhibitory and Antifouling Activities of New Bromotyrosine Metabolites from the Polynesian Sponge Pseudoceratina n. sp., Marine drugs, 2020, 18 (5), pp. 272