Protection against Radiotherapy-Induced Toxicity

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Hall, Susan
Rudrawar, Santosh
Zunk, Matthew
Bernaitis, Nijole
Arora, Devinder
McDermott, CatherineM
Anoopkumar-Dukie, Shailendra
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2016
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http://creativecommons.org/licenses/by/4.0/
Abstract

Radiation therapy is a highly utilized therapy in the treatment of malignancies with up to 60% of cancer patients receiving radiation therapy as a part of their treatment regimen. Radiation therapy does, however, cause a wide range of adverse effects that can be severe and cause permanent damage to the patient. In an attempt to minimize these effects, a small number of compounds have been identified and are in use clinically for the prevention and treatment of radiation associated toxicities. Furthermore, there are a number of emerging therapies being developed for use as agents that protect against radiation-induced toxicities. The aim of this review was to evaluate and summarise the evidence that exists for both the known radioprotectant agents and the agents that show promise as future radioprotectant agents

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Antioxidants
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5
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3
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© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
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Radiation therapy
Biochemistry and cell biology
Medical biochemistry and metabolomics
Pharmacology and pharmaceutical sciences
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