Catheter Effects in Organ Perfusion Experiments.

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Anissimov, YG
Bracken, AJ
Roberts, MS
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2002
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Abstract

In a typical isolated organ perfusion experiment, a substance is injected upstream of an organ and then collected at some distance downstream. To reach the organ from the injection site, and then from the organ to the collector, a solute passes through catheters, usually tubes with circular cross-sections. Catheters cause distortion to the concentration-time profile of the perfusion. In this paper, we analyse catheter distribution kinetics from a mathematical point of view, develop the function most suitable for modeling this distribution and successfully apply this function to experimental data.

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Journal of Theoretical Biology
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214
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Mathematical sciences
Biological sciences
Information and computing sciences
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