Editorial: Leptin in Physiology and Disease

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Hryciw, Deanne H
Singh, Harbindar Jeet
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2022
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http://creativecommons.org/licenses/by/4.0/
Abstract

Since the discovery of leptin, a product of the ob gene, in 1994, there has been a large amount of research identifying the role of this hormone in the maintenance of normal physiology and in disease states. Specifically, the adipokine leptin plays a significant role in the maintenance of homeostasis through modulating cell signalling pathways involved in energy balance and food intake. More recent research has investigated the role of leptin in pathways not linked to satiety, with researchers demonstrating that leptin contributes to other physiological processes including inflammation, respiratory function, bone metabolism, and development. Furthermore, this research has been extended to demonstrate leptin’s mechanistic links to pathologies associated with diseases, particularly those related to obesity.

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Frontiers in Physiology
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13
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© 2022 Hryciw and Singh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Medical physiology
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Hryciw, DH; Singh, HJ, Editorial: Leptin in Physiology and Disease, Frontiers in Physiology, 13, pp. 950686
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