Novel Approaches in the Treatment of Virus- Induced Inflammatory Disease
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Mahalingam, Suresh
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Herrero, Lara
Tripp, Ralph
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Abstract
This PhD thesis combines four chapters on different fields of basic research and sets the focus on two circulating viruses of global concern, the orthomyxovirus influenza A virus (IAV) and the alphavirus Ross River virus (RRV). The first three chapters include swine influenza A virus (sIAV) surveillance for the detection and characterisation of IAV subtypes, an in vitro high throughput screening (HTS) on host micro RNAs (miRNAs) for the discovery of novel anti-IAV (H7N9) targets and their underlying mechanisms, and an approach to reduce disease pathogenesis in mice infected with H7N9 by targeting the pro-inflammatory factor CCL2. In a fourth chapter, drug repurposing with the interleukin-1 (IL-1) inhibitor anakinra was investigated to treat RRV-induced bone loss in mice. By combining these four chapters, a broad range of drug discovery is covered in this PhD thesis; Surveillance, HTS target discovery and the application of drug repurposing in animal models of viral diseases.
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Thesis (PhD Doctorate)
Degree Program
Doctor of Philosophy (PhD)
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Institute for Glycomics
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The author owns the copyright in this thesis, unless stated otherwise.
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Subject
Orthomyxovirus influenza A virus (IAV)
Alphavirus Ross River virus (RRV)
Swine influenza A virus (sIAV)
Drug repurposing
Virus- induced inflammatory disease