The Anthropocene is characterised by people’s significant influences on global systems, which generate both high levels of uncertainty and profound change in our lifetime. We must start to better engage with what it might mean to inhabit and know the world differently, especially as we experience extensive loss and change, and because grief is increasingly with us. At the same time, we must better engage with our emotions productively and find hope through active, conscious processing and mourning. In this commentary, we explore the potential of engaging in nature-based tourism to help us grapple with, process, and positively engage with the emotions of the Anthropocene. We gained insights about such potential for healing by collaborating with two eco-tourism enterprises in Australia: Mount Barney Lodge in Southeast Queensland and Salt and Bush Eco Tours in the Peel River Region on the west coast of Australia. We found that nature immersion can heal and renew. Moreover, guides who know about and are connected to or living closely with nature play critical roles as interpreters or intermediaries with nature. They can also inspire gratitude and positive emotions by encouraging us to (re)connect with nature and provide new and transformative perspectives that bring comfort and motivate action.