A pilot study to profile salivary angiogenic factors to detect head and neck cancers
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Wan, Y
Cheong, HJ
Perry, C
Punyadeera, C
Griffith University Author(s)
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Abstract
Background: Early diagnosis of head and neck squamous cell carcinoma (HNSCCs) is an appealing way to increase survival rates in these patients as well as to improve quality of life post-surgery. Angiogenesis is a hallmark of tumor initiation and progression. We have investigated a panel of angiogenic factors in saliva samples collected from HNSCC patients and controls using the Bio-Plex ProT M assays. Methods: We have identified a panel of five angiogenic proteins (sEGFR, HGF, sHER2, sIL-6Ra and PECAM-1) to be elevated in the saliva samples collected from HNSCC patients (n = 58) compared to a control cohort (n = 8 smokers and n = 30 non-smokers). Results: High positive correlations were observed between the following sets of salivary proteins; sEGFR:sHER2, sEGFR:HGF, sEGFR:sIL-6Rα, sHER2:HGF and sHER2:sIL6Ra. A moderate positive correlation was seen between FGF-basic and sEGFR. Conclusion: We have shown that angiogenic factor levels in saliva can be used as a potential diagnostic biomarker panel in HNSCC.
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BMC Cancer
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18
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1
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© The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Oncology and carcinogenesis
Science & Technology
Life Sciences & Biomedicine
Oncology
Angiogenesis
Saliva
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van der Merwe, L; Wan, Y; Cheong, HJ; Perry, C; Punyadeera, C, A pilot study to profile salivary angiogenic factors to detect head and neck cancers, BMC Cancer, 2018, 18 (1), pp. 734