Place of residence significantly influences health, well-being, and quality of life. This study reviewed the grey literature using evidence mapping and thematic analyses to identify, describe, and synthesise service system knowledge concerning children and families experiencing place-based disadvantage. Twenty-four documents were reviewed and four key themes identified (1) infrastructure and safety; (2) access and navigation of services; (3) gaps in the support system and (4) the user experience. Our findings highlight target areas to improve the outcomes of children and families in the context of spatial deprivation, and notes a need for better coordination and management of service system knowledge.