An expeditious and atom-economic synthesis of lead-like, medicinally important 4,5-dihydropyrazolo[1,5-a]pyrazin-6-ones

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Mujumdar, Prashant
Sapegin, Alexander
Dorogov, Mikhail
Krasavin, Mikhail
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2014
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Abstract

We have developed an expeditious and atom-economic synthesis of lead-like, privileged 4,5-dihydropyrazolo[1,5-a]pyrazin-6-ones, which is based on Sonogashira coupling and a two-step condensation with hydrazine hydrate leading to two ring-forming events, with full control over the two elements of diversity present.

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Tetrahedron Letters

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55

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42

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Organic Chemistry not elsewhere classified

Medicinal and Biomolecular Chemistry

Organic Chemistry

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