Interstitial lung fluid balance in healthy lowlanders exposed to high-altitude
File version
Accepted Manuscript (AM)
Author(s)
Stewart, GM
Marck, JW
Summerfield, DT
Issa, AN
Johnson, BD
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
Size
File type(s)
Location
Abstract
We aimed to assess lung fluid balance before and after gradual ascent to 5150 m. Lung diffusion capacity for carbon monoxide (DLCO), alveolar-capillary membrane conductance (DmCO) and ultrasound lung comets (ULCs) were assessed in 12 healthy lowlanders at sea-level, and on Day 1, Day 5 and Day 9 after arrival at Mount Everest Base Camp (EBC). EBC was reached following an 8-day hike at progressively increasing altitudes starting at 2860 m. DLCO was unchanged from sea-level to Day 1 at EBC, but increased on Day 5 (11 ± 10%) and Day 9 (10 ± 9%) vs. sea-level (P ≤ 0.047). DmCO increased from sea-level to Day 1 (9 ± 6%), Day 5 (12 ± 8%), and Day 9 (17 ± 11%) (all P ≤ 0.001) at EBC. There was no change in ULCs from sea-level to Day 1, Day 5 and Day 9 at EBC. These data provide evidence that interstitial lung fluid remains stable or may even decrease relative to at sea-level following 8 days of gradual exposure to high-altitude in healthy humans.
Journal Title
Respiratory Physiology and Neurobiology
Conference Title
Book Title
Edition
Volume
243
Issue
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
© 2017 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
Item Access Status
Note
Access the data
Related item(s)
Subject
Cardiovascular medicine and haematology
Medical physiology
Neurosciences
High-altitude pulmonary oedema
Hypoxia
Lung diffusing capacity
Ultrasound lung comets
Persistent link to this record
Citation
Taylor, BJ; Stewart, GM; Marck, JW; Summerfield, DT; Issa, AN; Johnson, BD, Interstitial lung fluid balance in healthy lowlanders exposed to high-altitude, Respiratory Physiology and Neurobiology, 2017, 243, pp. 77-85