Cell Secretome from Mesenchymal Stem Cells for Periodontal Regeneration

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Chen, Bin
Li, Lili
Zhang, Xiaoxin
Liu, Qing
Xiao, Yin
Yan, Fuhua
Griffith University Author(s)
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2024
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Periodontitis affects approximately 50% of the global adult population and results in varying degrees of periodontal destruction. The regeneration of periodontal tissue is in great demand but is currently difficult to achieve. The cell secretome from mesenchymal stem cells (CSmsc) has shown promise in promoting periodontal regeneration and is a translational alternative for mesenchymal stem cell (MSC)-based therapy. The practical components of CSmsc are soluble secretions and extracellular vesicles. The mechanisms of CSmsc-induced tissue regeneration may lie in its regulation of the local microenvironment, modulating immune cells such as macrophages and stimulating local host MSCs, a cell population with a direct effect on tissue regeneration. Therefore, CSmsc has been suggested as a promising cell-based product for future periodontal regenerative therapy. Hence, more studies should be conducted to analyse the effective components of the MSC secretome, explore the underlying mechanisms, and obtain functional CSmsc for clinical translation in periodontal regeneration.

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Regenerative Medicine and Dentistry

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1

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1

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© 2024 by the authors. This work is licensed under a Creative Commons Attribution 4.0 International License.

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Chen, B; Li, L; Zhang, X; Liu, Q; Xiao, Y; Yan, F, Cell Secretome from Mesenchymal Stem Cells for Periodontal Regeneration, Regenerative Medicine and Dentistry, 2024, 1 (1), pp. 4

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