In this research, attempt was made to unveil gender differences in information and communication technology (ICT) usage, perceived system attributes, and entrepreneurial traits among Malaysia entrepreneurs. Results show that male entrepreneurs are more flexible and persevering as compared to female entrepreneurs. Risk-taking propensity is an important technology usage determinant among female entrepreneurs but not among male entrepreneurs. Innovativeness is associated with usage by male and female entrepreneurs. Mean perceptions of system's usefulness and ease of use are significantly higher for female entrepreneurs than for male entrepreneurs. There is a strong impact of perceived usefulness on system usage by male and female entrepreneurs. There is no significant association between perceived ease of use and usage. Overall ICT usage, usage of basic and advanced systems, and systems usage for administrative, planning, and control purposes do not differ based on gender.