This chapter examines the depth of damage to music practices in places where armed conflict has torn apart the social and cultural fabric of a society. It demonstrates how such conditions can be understood and analyzed through the perspective of “cultural ecosystems,” which recognizes music practices as evolving and flourishing in a multidimensional and dynamic space that is here termed a “musisphere.” Much as a biosphere can be disturbed by ecological disbalances, human conflict can have profound and disastrous impact on a musisphere, the space that contains the sum of biotic and abiotic forces and factors that impact on the vitality of any music practice. The analysis considers the impact on music practices of conflict and post-conflict conditions across five key domains, focusing primarily on human agency. It augments this with consideration of a model of six critical junctures for (re)building music practices post-conflict in close collaboration with communities, in order to revitalize or develop new musical practices.