Objective Complication rates from peripherally inserted central catheters (PICC) insertions are reportedly high. The aim of this study is to report positive patient outcomes from a nurse-led PICC insertion team. Methods We conducted a retrospective analysis of consecutive adults that had a PICC line inserted between 1 January and 31 December 2017. The study examined the prevalence of major complications – catheter-related bloodstream infection (CRBSI) and catheter-related deep vein thrombosis (CRDVT). Results The total number of PICCs inserted was 661.The total number of catheter days was 10,732 and the average catheter dwell time was 22 days. Four cases of CRBSI (0.37 per 1000 catheter days) were observed. Five patients had CRDVT (0.46 per 1000 catheter days). Conclusions The nurse-led PICC service demonstrated minimal infection and thrombus complications. Nurses who are trained to insert PICCs can improve patient flow and provide cost savings.