Cardiovascular disease remains one of the largest causes of death in the world. Many people who suffer from pre-existing cardiovascular diseases often develop heart failure over time. Heart failure is described as the inability of the heart to pump sufficient blood around the body to meet its metabolic needs [1]. Heart failure is also commonly seen in the aged population. In the heart there are two major types of cells found; these are the myocyte and non-myocyte cells. The non-myocyte cells include endothelial cells, smooth muscle cells and fibroblast cells [2]. Of these cells, the cardiac fibroblast cells have been implicated in the heart failure process. Cardiac fibroblast cells make up approximately 70% of all cell type within the heart [3]. One of the main important roles of the cardiac fibroblast cells is in maintaining the structural integrity of the heart. Moreover, after a cardiac event such as a heart attack, these cardiac fibroblast cells can transform into cardiac myofibroblast cells which contribute to the detrimental effects observed in heart failure [2]. Cardiac myofibroblast cells only arise in injured hearts and produce collagen for wound repair [2]. However, this continues to persist after the initial injury for many years, which leads to over production of collagen and rigidity of the myocardium wall thus contributing to heart failure. [...]