The present research is the first of its kind in Australia to simultaneously examine individual, family and neighbourhood predictors of adolescent antisocial behaviour. The study draws on two key data sources- Australian Bureau of Statistics census data and the Mater University Study of Pregnancy (MUSP). The MUSP is a prospective longitudinal study of mothers and their children in Brisbane, Australia; the current project draws on data from birth through to adolescence (age 14 years). The study found that less than one percent of variation in antisocial behaviour was attributable to the statistical local area (SLA). Subsequent models of both SLA-level variables (neighbourhood disadvantage, immigration concentration and residential mobility) and individual and familial variables, showed that the strongest predictors of adolescent antisocial behaviour are those which measure disruptions in parenting processes, poor school performance and early childhood aggression. The findings suggest that programs that aim to enhance parenting practices, including improving communication, supervision and monitoring of children, are important in reducing adolescent antisocial behaviour.