An extended nonlinear layered finite element method (LFEM) is used to investigate the influence of openings and shear stud reinforcement (SSR) on the behaviour of reinforced concrete slab - edge column connections. In all, ten large-scale slab - edge column connections tested previously are analyzed. The laboratory test variables were the size and location of the openings in the vicinity of an edge column and the existence of SSR. The numerical results of the load-deflection response, the ultimate strength, and the crack patterns are compared with the experimental findings and good agreement is achieved. A numerical study on two connections is also carried out to determine the influence of the locations of opening in slab - edge column connections with SSR. Discussion on code provisions for slabs with openings is provided. The comparative and numerical studies confirm the accuracy, reliability, and effectiveness of the LFEM in the analysis of slab - edge column connections with both openings and SSR.