BACKGROUND One in seven or 15% of the world’s population live with a disability [1]. Upper limb loss has been reported to range from 1.2 to 4.4 per 10 000 people to 11.6 per 100 000 [2, 3]. Rehabilitation guidelines ensures that an amputee’s needs on all levels are taken into consideration whilst allowing a consistent approach from surgery through to lifelong skills. Currently there is no clinical guideline available that specifically addresses treatment for upper limb loss rehabilitation. AIM Provide a cohesive clinical guideline for upper limb amputation that ensures clinicians and users to experience safe and effective standard rehabilitation pathway to support their individual rehabilitation. METHOD A literature review was undertaken as part of the OneHand Project funded by the European Union’s Horizon 2020 research and innovation programme. We reviewed evidence-based as well as grey literature. An expert panel consisting of therapists and amputees globally provided feedback while the guidelines were formulated. RESULTS As a result of the literature review and expert feedback, the guidelines have been separated into key phases that include acute or postsurgical, subacute or pre-prosthetic training, basic prosthetic training and advanced long-term rehabilitation or ongoing care. These phases outline key personnel to be involved at each stage, as well as key elements that will ideally be included for each phase. Alongside these guidelines are key resources to support the amputee along their rehabilitation journey. These include frequently asked questions (FAQs) for upper limb amputees and regularly used rehabilitation exercises for each level of upper limb amputation. DISCUSSION AND CONCLUSION The next phase of development of these guidelines will be to engage more widely with all stakeholders including the ISPO communities of interest. We anticipate that this final stage of the preparation will ensure that these guidelines can be utilised by rehabilitation teams both in low income to high income countries to encourage safe and efficient access to services globally.