Status Epilepticus Australasian Registry for Children: A pilot prospective, observational, cohort study of paediatric status epilepticus

No Thumbnail Available
File version
Furyk, Jeremy S
George, Shane
Phillips, Natalie
Emeto, Theophilus
Watt, Kerrianne
O'Brien, Sharon
Riney, Kate
Wilson, Catherine
Hearps, Stephen JC
Borland, Meredith L
Dalziel, Stuart R
Babl, Franz E
Griffith University Author(s)
Primary Supervisor
Other Supervisors
File type(s)

Objective: Paediatric status epilepticus (SE) has potential for long-term sequelae. Existing data demonstrate delays to aspects of care. The objective of the present study was to examine the feasibility of collecting data on children with paediatric SE and describe current management strategies in pre-hospital and in-hospital settings. Methods: A pilot, prospective, observational cohort study of children 4 weeks to 16 years of age with SE, in four EDs in Australia. Clinical details including medications administered, duration of seizure and short-term outcomes were collected. Follow up occurred by telephone at 1 month. Results: We enrolled 167 children with SE. Mean age was 5.4 years (standard deviation [SD] 4.1), and 81 (49%) male. Median seizure duration was 10 min (interquartile range 7–30). Midazolam was the first medication administered in 87/100 (87%) instances, mean dose of 0.21 mg/kg (SD 0.13). The dose of midazolam was adequate in 30 (35%), high (>0.2 mg/kg) in 44 (51%) and low (<0.1 mg/kg) in 13 (15%). For second-line agents, levetiracetam was administered on 33/55 (60%) occasions, whereas phenytoin and phenobarbitone were administered on 11/55 (20%) occasions each. Mean dose of levetiracetam was 26.4 mg/kg (SD 13.5). One hundred and four (62%) patients were admitted to hospital, with 13 (8%) admitted to ICU and seven (4%) intubated. Conclusion: In children presenting with SE in Australia medical management differed from previous reports, with midazolam as the preferred benzodiazepine, and levetiracetam replacing phenytoin as the preferred second-line agent. This pilot study indicates the feasibility of a paediatric SE registry and its utility to understand and optimise practice.

Journal Title

Emergency Medicine Australasia

Conference Title
Book Title




Thesis Type
Degree Program
Publisher link
Patent number
Grant identifier(s)
Rights Statement
Rights Statement
Item Access Status
Access the data
Related item(s)

Emergency medicine

Science & Technology

Life Sciences & Biomedicine

Emergency Medicine


status epilepticus

Persistent link to this record

Furyk, JS; George, S; Phillips, N; Emeto, T; Watt, K; O'Brien, S; Riney, K; Wilson, C; Hearps, SJC; Borland, ML; Dalziel, SR; Babl, FE, Status Epilepticus Australasian Registry for Children: A pilot prospective, observational, cohort study of paediatric status epilepticus, Emergency Medicine Australasia, 2022, 34 (5), pp. 801-807