Recent advances in liquid biopsy technologies for cancer biomarker detection

Loading...
Thumbnail Image
File version

Version of Record (VoR)

Author(s)
Soda, Narshone
Clack, Kimberley
Shiddiky, Muhammad JA
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2022
Size
File type(s)
Location
Abstract

Gene mutation is associated with cancer and the dissemination of circulating biomarkers through the blood represents a vital transitional step that exemplifies the shift from localized to systemic disease. The detection and characterization of circulating tumor biomarkers at an early stage is therefore essential as a conventional approach to monitor and suppress the initiation of overt metastatic disease. Currently, the genetic profiles of solid tumors are obtained from needle biopsies, which provides a glimpse of tumor heterogeneity. Furthermore, some tumor entities such as lung cancer are situated at remote sites and a needle biopsy can be very difficult and can increase chances of tumor seeding. Thus, the analysis of circulating tumor cells (CTCs) and cell-free circulating nucleic acids (in particular circulating tumor DNA-ctDNA) and tumor derived exosomes released into the peripheral blood from the primary tumor and/or metastatic deposits by minimally invasive means, can provide the full genetic landscape of all cancerous lesions, and can enable systematic tracking of genomic evolution. Herein, we explore how circulating biomarkers (CBs) detectable in bodily fluids can be utilized for diagnosis, prognosis evaluation and prediction of response to treatments. We also discuss the current and emerging methods for analysing CBs as well as biological and technical challenges. Deficiencies of detection methods are identified, with subsequent critical overview of methods to address them.

Journal Title

Sensors & Diagnostics

Conference Title
Book Title
Edition
Volume

1

Issue

3

Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement

© 2022 The Author(s). This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Item Access Status
Note
Access the data
Related item(s)
Subject

Oncology and carcinogenesis

Liquid biopsies

Persistent link to this record
Citation

Soda, N; Clack, K; Shiddiky, MJA, Recent advances in liquid biopsy technologies for cancer biomarker detection, Sensors & Diagnostics, 1 (3), pp. 343-375

Collections