In the clinical setting, simulation is emerging as an important educational technology for learning about contemporary clinical care. The aim of this case study was to illustrate the feasibility of simulation as a research translation mechanism. Designing and delivering a simulated learning activity for delirium prevention was a key implementation strategy in a larger study focused on translating research evidence into practice. Using evidence about delirium prevention, and in collaboration with key stakeholders, the simulation team developed a delirium prevention scenario that was conducted four times with nurses in the participating ward. This study suggests that the use of simulation design and delivery as a research translation mechanism is feasible. Based on this experience, further research into how simulations can function as research translation mechanisms is recommended, with a view to improve patient outcomes through supported practice change.