Emerging understanding of dosimetric factors impacting on dysphagia and nutrition following radiotherapy for oropharyngeal cancer

Loading...
Thumbnail Image
File version

Accepted Manuscript (AM)

Author(s)
Cartmill, Bena
Cornwell, Petrea
Ward, Elizabeth
Davidson, Wendy
Nund, Rebecca
Bettington, Catherine
Rahbari, Reza Masoud
Poulsen, Michael
Porceddu, Sandro
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2013
Size
File type(s)
Location
License
Abstract

Background Research has reported relationships between 3-dimensional (3D) radiation dose to head and neck structures and consequential swallowing/nutritional outcomes. However, this evidence is preliminary. The current study aimed to identify which reported dose constraints identified functional impairment at 6 months posttreatment. Methods Dose constraints with reported relationships to swallowing and nutrition were identified through a systematic literature review. Dose-volume histograms for 12 patients with T1-T3 oropharyngeal cancer treated with 3D conformal radiotherapy determined dosages delivered to specific structures. Doses were examined in relation to published dose constraints and the swallowing and nutritional outcomes at 6 months posttreatment. Results In all, 66% of the reported mean, maximum, and partial doses to 8 structures correctly identified swallowing and nutrition outcomes at 6 months. Conclusion The relationships observed between known dosimetric constraints and functional outcomes highlight the potential for dosimetric data to assist in prognosis and treatment. Systematic research is required to refine dosimetric parameters and the impact on functional outcomes.

Journal Title

Head & Neck

Conference Title
Book Title
Edition
Volume

35

Issue

8

Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement

© 2013 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Emerging understanding of dosimetric factors impacting on dysphagia and nutrition following radiotherapy for oropharyngeal cancer, Head & Neck, Volume 35, Issue 8, 2013, Pages 1211-1219, which has been published in final form at https://doi.org/10.1002/hed.23040. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)

Item Access Status
Note
Access the data
Related item(s)
Subject

Clinical sciences

Dentistry

Radiation therapy

Persistent link to this record
Citation
Collections